ChemicalBook > CAS DataBase List > L-655,708
L-655,708
- Product Name
- L-655,708
- CAS No.
- 130477-52-0
- Chemical Name
- L-655,708
- Synonyms
- MSD;L-655,708;L 655708,L655708;ETHYL (S)-11,12,13,13A-TETRAHYDRO-7-METHOXY-9-OXO-9H-IMIDAZO[1,5-A]PYRROLO[2,1-C][1,4]BENZODIAZEPINE-1-CARBOXYLATE;Ethyl (S)-11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate;11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1.5-a]pyrrolo[2.1-c][1.4]benzodiazepine-1-carboxylicacidethylester;(S)-ethyl 7-methoxy-9-oxo-11,12,13,13a- tetrahydro-9H-benzo[e]imidazo[5,1-c]pyrrolo[1,2-a][1,4]diazepine-1-carboxylate;11,12,13,13A-TETRAHYDRO-7-METHOXY-9-OXO-9H-IMIDAZO[1,5-A]PYRROLO[2,1-C][1,4]BENZODIAZEPINE-1-CARBOXYLIC ACID, ETHYL ESTER;9H-IMidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid, 11,12,13,13a-tetrahydro-7-Methoxy-9-oxo-, ethyl ester, (13aS)-;9H-IMidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid, 11,12,13,13a-tetrahydro-7-Methoxy-9-oxo-, ethyl ester, (13aS)- (011-14426_500Mg)
- CBNumber
- CB4345633
- Molecular Formula
- C18H19N3O4
- Formula Weight
- 341.36
- MOL File
- 130477-52-0.mol
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L-655,708 Property
- Melting point:
- 175-176 °C
- Boiling point:
- 584.4±50.0 °C(Predicted)
- Density
- 1.42±0.1 g/cm3(Predicted)
- storage temp.
- Desiccate at +4°C
- solubility
- DMSO: 6 mg/mL
- form
- powder
- pka
- 1.49±0.20(Predicted)
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Safety
- WGK Germany
- 3
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- L9787
- Product name
- L-655,708
- Purity
- ≥98% (HPLC), powder
- Packaging
- 5mg
- Price
- $131
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- L9787
- Product name
- L-655,708
- Purity
- ≥98% (HPLC), powder
- Packaging
- 25mg
- Price
- $522
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 30322
- Product name
- L-655,708
- Packaging
- 5mg
- Price
- $106
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 30322
- Product name
- L-655,708
- Packaging
- 50mg
- Price
- $570
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 30322
- Product name
- L-655,708
- Packaging
- 10mg
- Price
- $167
- Updated
- 2024/03/01
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L-655,708 Chemical Properties,Usage,Production
Uses
L-655,708 has been used as an α5 GABAA receptor inverse agonist to inhibit the discriminative stimulus of propofol in a dose-dependent manner.
Biological Activity
Potent, selective inverse agonist for the benzodiazepine site of GABA A receptors containing the α 5 subunit (K i = 0.45 nM). Displays 50-100-fold selectivity over GABA A receptors containing α 1, α 2, α 3 or α 6 subunits in combination with β 3 and γ 2. Enhances LTP in? a mouse hippocampal slice model and increases spatial learning, without displaying proconvulsant activity.
Biochem/physiol Actions
L-655,708 is an inverse agonist of the α5 γ-Aminobutyric acid type A (GABAA) receptor. It has an ability to increase cognition in rats.
storage
Desiccate at +4°C
L-655,708 Preparation Products And Raw materials
Raw materials
Preparation Products
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L-655,708 Suppliers
130477-52-0, L-655,708Related Search:
[3H]-L-655,708,L-655,708, [1',1',1'-3H]
2-(1H-IMIDAZOL-1-YL)BENZENECARBOXAMIDE
2-IMIDAZOL-1-YL-BENZALDEHYDE
4-(5-METHYL-1H-IMIDAZOL-1-YL)PHENOL
4-(1H-IMIDAZOL-4-YL)-BUTYLAMINE
1-[2-(1H-IMIDAZOL-1-YL)PHENYL]METHANAMINE
L-655,708